Agammaglobulinemia, hypogammaglobulinemia, immune deficiency
Child, adult:Gamimune N: 100-200 mg/kg or 2-4 ml/kg IV q month. Infusion at 0.01-0.02 ml/kg/min × 30 min, then increase to max 0.08 ml/kg/min for rest of infusion. Gammagard S/D: 200-400 mg/kg IV, then 100 mg/kg q month. Start infusion at 0.5 ml/kg/h, increase to max 4 ml/kg/h. Gammar-P IV: 200-400 mg/kg q 3-4 wk. Infusion at 0.01 ml/kg/min, increase to 0.02 ml/kg/min after 15-30 min, with gradual increase to 0.06 ml/kg/min. Iveegam: 200 mg/kg IV q month. If response inadequate, increase up to 800 mg/kg or give more often. Infusion at 1-2 ml/min. Polygam S/D: 100 mg/kg IV q month 1st dose of 200-400 mg/kg may be given.Start infusion at 0.5 ml/kg/h, increase to max of 4 ml/kg/h. Sandoglobulin: 200 mg/kg IV q month, start with 0.5-1 ml/min of 3% solution; increase up to 2.5 ml/min gradually after 15- 30 min. Venoglobulin-I: 200 mg/kg IV q month; increase to 300-400 mg/kg; may be repeated > once q month. Infusion at 0.01-0.02 ml/kg/min × 30 min, then increase to = 0.04 ml/kg/min if tolerated. Venoglobulin-S: 200 mg/kg IV q month. Increase to 300-400 mg/kg q month or give more often if inadequate IgI levels. Start infusion at 0.01-0.02 ml/kg/min × 30 min, then increase 5% solution to 0.04 ml/kg/min and 10% solution to 0.05 ml/kg/min if tol.
Hepatitis A exposure
Child, adult: 0.02-0.04 ml/kg IM ASAP after exposure. Up to 0.1 ml/kg after prolonged or intense exposure.
Measles exposure
Child, adult: 0.25 ml/kg IM within 6 day after exposure.
Postexposure prophyx of measles
Child, adult: 0.5 ml/kg IM within 6 day after exposure.
Chickenpox exposure
Child, adult: 0.6-1.2 ml/kg IM as soon as exposed.
Idiopathic thrombocytopenic purpura
Child, adult: 400 mg/kg Sandoglobulin IV × 2-5 consecutive day; or 400 mg/kg Gamimune N 5% × 5 day or 1,000 mg/kg Gamimune N 10% × 1-2 day. Maintenance dose 400-1,000 mg/kg IV Gamimune N 10% as single infusion to maintain platelet count > 30,000/m3. |